Understanding how certain proteins help repair DNA and maintain genome stability in breast cancer.
Official title: The role of SWI/SNF chromatin remodelers in homologous recombination and genome stability
Funded at Midwestern University · NIH-10515147 · Data updated 2026-11-12
This study is looking at how certain proteins in breast cancer cells help fix damaged DNA, which could lead to better treatments and make chemotherapy work more effectively for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Midwestern University NIH-funded |
| Lab location | 1 site (Downers Grove, United States) |
| Project start | August 10, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $449,330 |
| NIH project number | 1R15CA267864-01A1 |
| Project ID | NIH-10515147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those whose tumors may involve mutations in SWI/SNF chromatin remodelers.
✕Less likely to help
Patients with non-breast cancers or those whose tumors do not involve SWI/SNF mutations may not benefit from this research.
What this research studies
This research investigates the role of SWI/SNF chromatin remodelers, specifically the proteins BRG1 and BRM, in the process of DNA repair and maintaining genome stability in breast cancer cells. By studying how these proteins interact with DNA damage and repair mechanisms, the research aims to uncover their potential as targets for enhancing the effectiveness of chemotherapy. The approach involves examining the recruitment of these proteins to sites of DNA damage and their influence on homologous recombination, a critical repair pathway. Patients may benefit from insights that could lead to improved treatment strategies for breast cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the effectiveness of chemotherapy in breast cancer patients.
How similar studies have gone: Other research has shown promising results in targeting chromatin remodelers for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
Midwestern University
Downers Grove, United States Active
Researchers
- Principal investigator: Velez-Cruz, Renier — Midwestern University
- Study coordinator: Velez-Cruz, Renier
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.