Understanding how certain proteins help Mycobacterium abscessus resist antibiotics
Official title: Role of ribosome modulating proteins in conferring Mycobacterium abscessus antibiotic resistance
Funded at Wadsworth Center · NIH-10897900 · Data updated 2026-11-12
This study is looking into how a tough germ called Mycobacterium abscessus manages to resist antibiotics, which could help doctors find better ways to treat infections caused by it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wadsworth Center NIH-funded |
| Lab location | 1 site (Menands, United States) |
| Project start | September 21, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $470,217 |
| NIH project number | 5R01AI155473-05 |
| Project ID | NIH-10897900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from skin, soft tissue, or pulmonary infections caused by Mycobacterium abscessus.
✕Less likely to help
Patients with infections caused by other types of bacteria that do not involve Mycobacterium abscessus may not benefit from this research.
What this research studies
This research investigates the mechanisms by which Mycobacterium abscessus, a highly antibiotic-resistant bacterium, survives despite treatment efforts. The study focuses on specific proteins that may play a role in the bacterium's resistance to antibiotics like amikacin and macrolides. By employing genetic, biochemical, and structural methods, researchers aim to uncover how these proteins function and contribute to antibiotic resistance. This knowledge could lead to improved treatment strategies for patients suffering from infections caused by this pathogen.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with infections caused by Mycobacterium abscessus.
How similar studies have gone: Previous research has shown promising results in understanding antibiotic resistance mechanisms in similar bacterial species, indicating potential for success in this area.
Where this research is happening
-
Wadsworth Center
Menands, United States Active
Researchers
- Principal investigator: Ghosh, Pallavi — Wadsworth Center
- Study coordinator: Ghosh, Pallavi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.