Understanding how certain proteins help maintain stable genomes in mammals
Mechanisms of Genomic Stability by Mammalian Argonaute Proteins
This study looks at how certain proteins in our cells help keep our DNA stable and prevent diseases like cancer, using mouse cells to learn more about how these proteins work with other molecules during cell division, which could eventually lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10874652 on NIH RePORTER |
What this research studies
This research investigates the role of mammalian Argonaute proteins in maintaining genomic stability, which is crucial for preventing mutations and diseases like cancer. By examining how these proteins interact with noncoding RNAs during cell division, the study aims to uncover mechanisms that ensure the proper replication of our genetic material. The research employs advanced techniques, including CRISPR, to explore these interactions in mouse stem cells, providing insights into potential risk factors for human diseases. Patients may benefit from a deeper understanding of how genomic stability is maintained, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with a family history of cancer or genetic disorders related to genomic instability.
Not a fit: Patients with stable genomes and no history of genetic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for age-related diseases, including cancer, by enhancing our understanding of genomic stability.
How similar studies have performed: Previous research has shown promising results in understanding RNA interference mechanisms in other organisms, suggesting potential for success in mammalian studies.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Zamudio, Jesse R — University of California Los Angeles
- Study coordinator: Zamudio, Jesse R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.