Understanding how certain proteins help maintain healthy blood vessels to prevent heart failure
Transcription Factor 4 Maintain Endothelial identity to Oppose Heart Failure
This study is looking at how certain proteins in the cells that line your blood vessels can help keep your heart healthy and prevent heart failure, and it’s for anyone interested in new ways to treat heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10982467 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins in endothelial cells, which line blood vessels, to understand how they can prevent heart failure. The study focuses on the communication between endothelial cells and fibroblasts, which are crucial for maintaining heart function and preventing fibrosis. By using advanced genetic tracing and computational modeling, researchers aim to uncover the molecular mechanisms that lead to endothelial dysfunction and cardiac fibrosis. This could lead to new therapeutic strategies for heart failure patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of heart failure or those with early signs of heart dysfunction.
Not a fit: Patients with advanced heart failure or those who do not have endothelial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of heart failure.
How similar studies have performed: Other research has shown promising results in targeting endothelial dysfunction as a therapeutic approach for heart failure, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Zhang, Lili — Boston Children's Hospital
- Study coordinator: Zhang, Lili
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.