Understanding how certain proteins help cells divide properly
Mechanistic Analysis of Kinesin-14 Motility and Regulation for Bipolar Spindle Assembly
This study is looking at how certain proteins help cells divide correctly, which is really important for keeping our bodies healthy and preventing issues like cancer, and it’s for anyone interested in understanding how our cells work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project ID | NIH-10650339 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that ensure accurate chromosome segregation during cell division, which is crucial for normal growth and development. It focuses on the role of specific proteins, known as kinesins, that help assemble the mitotic spindle, a structure responsible for separating chromosomes. By studying these proteins in detail, the researchers aim to uncover how they work together to prevent errors that can lead to conditions like cancer. The research involves reconstituting these spindles in a controlled laboratory setting to observe their behavior and interactions.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals at risk for cancers associated with aneuploidy or those with genetic predispositions to such conditions.
Not a fit: Patients with conditions unrelated to cell division errors or aneuploidy may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer prevention and treatment by improving our understanding of cell division errors.
How similar studies have performed: Other research has shown success in understanding the roles of kinesins in cell division, indicating that this approach is built on established findings in the field.
Where this research is happening
Corvallis, United States
- Oregon State University — Corvallis, United States (Active)
Researchers
- Principal investigator: Qiu, Weihong — Oregon State University
- Study coordinator: Qiu, Weihong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.