Understanding how certain proteins help cells communicate and function.
Official title: Phospholipase C Isozymes
Funded at Univ of North Carolina Chapel Hill · NIH-11057726 · Data updated 2026-11-12
This study is looking at how certain proteins help cells talk to each other and respond to signals, which could help us understand how our bodies work in both health and illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $384,915 |
| NIH project number | 5R35GM149299-03 |
| Project ID | NIH-11057726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve disrupted cellular signaling, such as certain cancers or immune disorders.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or those who do not have any known biochemical signaling issues may not benefit from this research.
What this research studies
This research investigates the role of phospholipase C isozymes in cellular communication and signaling. By examining how these proteins interact with various receptors on cell membranes, the study aims to uncover the fundamental principles of how cells transmit information. The approach involves detailed structural and biochemical analyses, allowing researchers to understand the specific responses of different cell types to various signals. This knowledge could lead to insights into how cellular processes are regulated in health and disease.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular signaling, potentially leading to new therapeutic strategies for diseases related to cell communication.
How similar studies have gone: Previous research has shown success in understanding cellular signaling mechanisms, indicating that this approach has the potential for meaningful discoveries.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Sondek, John E — Univ of North Carolina Chapel Hill
- Study coordinator: Sondek, John E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.