Understanding how certain proteins help build cilia that move cells and fluids.
Function of Ruvbl1-Ruvbl2 in dynein arm assembly in motile ciliated epithelial cells
This study is looking at how two specific proteins help build tiny structures called cilia that are important for movement in our bodies, and it's for anyone interested in understanding conditions like primary ciliary dyskinesia (PCD) that can cause problems with these movements.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10945178 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins, Ruvbl1 and Ruvbl2, in the assembly of dynein arms, which are essential for the movement of cilia in cells. Cilia are important for various bodily functions, and defects in their movement can lead to serious health issues, such as primary ciliary dyskinesia (PCD). The researchers will use zebrafish, mice, and cultured cells to explore how these proteins contribute to the proper formation and function of cilia. By understanding these mechanisms, the research aims to identify potential therapeutic targets for conditions related to ciliary dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary ciliary dyskinesia or those experiencing related respiratory issues.
Not a fit: Patients without ciliary dysfunction or those with unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with primary ciliary dyskinesia and other related conditions.
How similar studies have performed: Previous research has shown promising results in understanding ciliary function and its implications for health, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sun, Zhaoxia — Yale University
- Study coordinator: Sun, Zhaoxia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.