Understanding how certain proteins help assemble ribonucleoprotein complexes important for cell function.
Integrated studies of DEAD-box ATPase function during large ribosomal subunit maturation
This study is looking at how certain proteins help put together important cellular structures that are needed for making proteins and processing genetic material, which could help us understand some cancers and developmental issues, ultimately benefiting patients by revealing how these proteins work in health and disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10747855 on NIH RePORTER |
What this research studies
This research investigates the role of DEAD-box ATPases in the assembly of ribonucleoprotein (RNP) complexes, which are crucial for processes like protein translation and mRNA splicing. By using a combination of genetic manipulation and biophysical techniques, the study aims to uncover how these proteins interact with RNA and other molecules to form functional complexes. This understanding could shed light on the mechanisms behind certain cancers and developmental disorders linked to defects in these proteins. Patients may benefit from insights gained about how these proteins function and their implications in disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with specific cancers or developmental disorders linked to DEAD-box protein defects.
Not a fit: Patients with conditions unrelated to DEAD-box proteins or those not affected by the diseases being studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancers and developmental disorders associated with DEAD-box protein dysfunction.
How similar studies have performed: Previous research has shown that understanding the function of similar proteins has led to significant advancements in cancer treatment, suggesting a promising avenue for this study.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Erzberger, Jan Peter — Ut Southwestern Medical Center
- Study coordinator: Erzberger, Jan Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.