Understanding how certain proteins function in the body
Official title: Structural characterization of large eukaryotic proteins containing both folded and disordered domains
Funded at Scripps Research Institute, the · NIH-10931318 · Data updated 2026-11-12
This study is looking at special proteins in our bodies that don’t have a fixed shape but are really important for how our cells work, especially since they are connected to serious health issues like cancer and diabetes, and it aims to understand how these proteins interact to help us learn more about their roles in these diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 21, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $460,000 |
| NIH project number | 5R35GM148226-02 |
| Project ID | NIH-10931318 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers, diabetes, cardiovascular diseases, or neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to protein dysregulation or those not affected by the diseases studied may not benefit from this research.
What this research studies
This research focuses on intrinsically disordered proteins (IDPs) that play crucial roles in cellular regulation and organization. It aims to characterize these proteins, which are abundant in humans and linked to serious diseases like cancer and diabetes, using a holistic approach rather than traditional methods that isolate protein regions. By studying the interactions between structured and disordered domains of these proteins, the research seeks to uncover their complex biological functions and mechanisms. This could lead to better insights into how these proteins contribute to various diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diseases associated with protein dysregulation.
How similar studies have gone: While the study of intrinsically disordered proteins is a growing field, this holistic approach is relatively novel and has not been extensively tested in prior research.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Wright, Peter Edwin — Scripps Research Institute, the
- Study coordinator: Wright, Peter Edwin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.