Understanding how certain proteins control the growth of intestinal stem cells.
Official title: Homeostatic control of intestinal stem cell renewal by two transcriptional coactivators
Funded at Emory University · NIH-10997769 · Data updated 2026-11-12
This study looks at how two proteins, YAP1 and NCOA3, help keep the cells in our intestines healthy and growing, using fruit flies to learn more about their role, which could eventually help us understand and treat conditions like colorectal cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31DK139740-01A1 |
| Project ID | NIH-10997769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of colorectal cancer or those at high risk for developing gastrointestinal disorders.
✕Less likely to help
Patients with non-gastrointestinal related conditions or those who do not have a family history of colorectal cancer may not benefit from this research.
What this research studies
This research investigates the mechanisms by which two specific proteins, YAP1 and NCOA3, regulate the renewal of intestinal stem cells, which are crucial for maintaining the health of the gastrointestinal tract. By using a model organism, the fruit fly, the study aims to uncover how these proteins interact and influence stem cell behavior. The findings could provide insights into the processes that lead to colorectal cancer and other gastrointestinal disorders, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for colorectal cancer and other gastrointestinal diseases by enhancing our understanding of stem cell regulation.
How similar studies have gone: Previous research has shown success in using similar models to understand stem cell regulation, indicating that this approach is promising.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Placentra, Victoria — Emory University
- Study coordinator: Placentra, Victoria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.