Understanding how certain proteins control lung inflammation caused by influenza viruses
ETS-family Transcription Factor Mediated Control of Pulmonary Inflammation Induced by Influenza Viruses
This study is looking at how a protein called ETV7 helps control inflammation in the lungs when someone has the flu, with the hope that understanding this could lead to better treatments for flu and other breathing problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10989937 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, ETV7, in regulating inflammation in the lungs during influenza virus infections. By using advanced techniques like CRISPR activation screening, the study aims to uncover how this protein influences the immune response and helps manage excessive inflammation. Patients may benefit from insights gained about how to better control lung inflammation, potentially leading to improved treatments for influenza and related respiratory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are at high risk for severe influenza complications, such as those with pre-existing respiratory conditions.
Not a fit: Patients who do not have respiratory issues or are not at risk for severe influenza complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce severe lung inflammation in patients with influenza infections.
How similar studies have performed: Previous research has shown success in using CRISPR technology to manipulate gene expression, suggesting that this approach may yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Heaton, Nicholas S — Duke University
- Study coordinator: Heaton, Nicholas S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.