Understanding how certain proteins control immune and metabolic functions in the body
Quantifying and modeling ligand-dependent control of RORγ dynamics via structural proteomics
This study is looking at how certain proteins in our bodies help control things like metabolism and immune responses, and it's trying to create new molecules that can interact with a specific protein called RORγ, which could lead to better treatments for conditions like cancer and metabolic disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10870190 on NIH RePORTER |
What this research studies
This research investigates how specific proteins, known as nuclear receptors, regulate important bodily functions such as metabolism and immune responses. By developing synthetic molecules that can interact with these proteins, the research aims to better understand their role in health and disease. The focus is on a particular protein called RORγ, which is involved in the differentiation of immune cells and has implications for conditions like cancer and metabolic disorders. Patients may benefit from insights gained into how these proteins can be targeted for new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders or immune-related conditions, particularly those involving T cells.
Not a fit: Patients with conditions unrelated to immune function or metabolism may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases related to metabolism and immune function, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in targeting nuclear receptors for therapeutic purposes, indicating that this approach may lead to significant advancements.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Griffin, Patrick Robert — University of Florida
- Study coordinator: Griffin, Patrick Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.