Understanding how certain proteins control cell signaling and communication
Official title: Investigation of Adhesion GPCR and Ric-8 protein control of heterotrimeric G proteins
Funded at University of Michigan at Ann Arbor · NIH-11051226 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells help them communicate and work together, especially in blood cells, to better understand their role in health and disease, which could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $548,655 |
| NIH project number | 5R35GM149539-03 |
| Project ID | NIH-11051226 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions linked to cell signaling abnormalities or blood-related disorders.
✕Less likely to help
Patients with unrelated conditions or those not affected by cell signaling issues may not receive any benefit from this research.
What this research studies
This research investigates the role of adhesion G protein-coupled receptors (GPCRs) and Ric-8 proteins in cell signaling and communication. By examining how these proteins interact and activate within cells, the research aims to uncover mechanisms that could influence various biological processes. The study employs biochemical, cell biological, and in vivo approaches, including the use of newly created mouse models, to explore different activation modes of adhesion GPCRs, particularly those found in blood cells. Patients may benefit from insights gained into how these proteins function in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cell signaling dysfunction.
How similar studies have gone: Previous research has shown promise in understanding GPCR mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Tall, Gregory Gordon — University of Michigan at Ann Arbor
- Study coordinator: Tall, Gregory Gordon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.