Understanding how certain proteins control cell movement
ARFs, ORPs and the control of cell migration
['FUNDING_OTHER'] · UNIVERSITY OF VIRGINIA · NIH-11004161
This study is looking at how certain proteins help control how cells move and stick together, especially in cancer, by focusing on how they respond to calcium signals, which could help us understand and improve treatments for cancer spread.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11004161 on ClinicalTrials.gov |
What this research studies
This research investigates the role of ADP-ribosylation factors (ARFs) and their regulators in controlling cell migration and adhesion. By focusing on specific proteins that respond to calcium signaling, the study aims to uncover how these proteins influence the movement of cells, particularly in the context of cancer metastasis. The researchers will explore the interactions between ARFs and other proteins to understand their function in cellular processes. This could lead to insights into how cells move and adhere, which is crucial for various physiological and pathological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions related to cancer metastasis or other diseases involving abnormal cell migration.
Not a fit: Patients with stable, non-migratory conditions or those not affected by cell adhesion issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer metastasis by targeting the mechanisms of cell migration.
How similar studies have performed: Previous research has shown success in understanding the roles of similar proteins in cell migration, indicating that this approach has potential for impactful findings.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CASANOVA, JAMES E. — UNIVERSITY OF VIRGINIA
- Study coordinator: CASANOVA, JAMES E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.