Understanding how certain proteins control cell growth and division
Regulation of cell proliferation by CRL ubiquitin ligases
This study is looking at how certain proteins help control cell growth and survival, which could lead to new treatments for diseases like cancer that involve problems with cell growth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11090721 on NIH RePORTER |
What this research studies
This research investigates the role of Cullin-RING Ubiquitin Ligase (CRL) complexes in regulating cell growth, proliferation, and survival. By exploring the mechanisms of the ubiquitin-proteasome system, the study aims to uncover how these complexes influence critical cellular processes such as the cell cycle and DNA damage response. The approach involves a combination of genetics and proteomics to identify and characterize the functions of various ubiquitin ligases, which may lead to new insights into cellular regulation. Patients may benefit from this research as it could reveal new therapeutic targets for diseases related to cell proliferation, such as cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions characterized by abnormal cell proliferation, such as cancer.
Not a fit: Patients with non-proliferative conditions or those not affected by cell cycle dysregulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the regulation of cell growth and division, potentially improving outcomes for patients with cancer and other proliferative disorders.
How similar studies have performed: Previous research has shown success in targeting the ubiquitin-proteasome system for therapeutic purposes, indicating that this approach has potential for meaningful advancements.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Pagano, Michele — New York University School of Medicine
- Study coordinator: Pagano, Michele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.