Understanding how certain proteins control cell death in inflammation
Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT Extension
This study is looking at how certain proteins work together to control a type of cell death related to inflammation, which could help us find new treatments for inflammatory diseases that affect adults.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11070340 on NIH RePORTER |
What this research studies
This research investigates the role of the FADD-caspase-8-FLIP complex in regulating a specific type of cell death called necroptosis, which is linked to inflammation. By using genetic models and laboratory experiments, the researchers aim to understand how these proteins interact with others to either promote or inhibit this cell death process. The findings could provide insights into how these mechanisms contribute to inflammatory diseases and overall health in adults. Patients may benefit from a better understanding of these processes, which could lead to new treatments for inflammatory conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with inflammatory diseases or conditions related to necroptosis.
Not a fit: Patients with non-inflammatory conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding necroptosis and its implications in inflammation, suggesting that this approach has potential for significant findings.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Green, Douglas R. — St. Jude Children's Research Hospital
- Study coordinator: Green, Douglas R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.