Understanding how certain proteins contribute to esophageal cancer development
Official title: Disruption of Transcription Networks in Esophageal Adenocarcinoma Tumorigenesis
Funded at University of Miami School of Medicine · NIH-10866608 · Data updated 2026-11-12
This study is looking into how long-term acid reflux might lead to esophageal cancer, and it's for anyone interested in understanding more about this condition and finding better treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 8, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,466,824 |
| NIH project number | 5P01CA268991-03 |
| Project ID | NIH-10866608 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with esophageal adenocarcinoma or those suffering from chronic gastroesophageal reflux disease.
✕Less likely to help
Patients with other types of esophageal cancer or those without a history of gastroesophageal reflux disease may not benefit from this research.
What this research studies
This research investigates the biological mechanisms behind esophageal adenocarcinoma (EAC), a type of cancer that has seen a dramatic increase in incidence. It focuses on how chronic gastroesophageal reflux disease (GERD) may lead to cancer by examining the interactions between specific proteins and their effects on cancer cell survival. The study utilizes advanced animal models, human tissues, and innovative technologies to explore these interactions and test potential new treatments. Patients may benefit from insights that could lead to improved therapies for EAC.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that significantly improve survival rates for patients with esophageal adenocarcinoma.
How similar studies have gone: Previous research has shown promising results in understanding the molecular mechanisms of esophageal cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: El-Rifai, Wael — University of Miami School of Medicine
- Study coordinator: El-Rifai, Wael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.