Understanding how certain proteins contribute to diseases like ALS and frontotemporal dementia
Functional and Pathological Assembly of Prion-like Domains
This study is looking at special parts of human proteins that can affect how our cells work and are connected to diseases like ALS and frontotemporal dementia, with the goal of figuring out how these proteins behave and how changes in them might lead to problems, which could help in finding new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11017705 on NIH RePORTER |
What this research studies
This research investigates prion-like domains (PrLDs) in human proteins, which are linked to various cellular functions and degenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The study aims to understand how these domains form functional assemblies that regulate cellular activities and how mutations can lead to disease by promoting harmful protein aggregation. By examining the dynamics of these protein interactions, the research seeks to uncover the underlying mechanisms that contribute to these conditions, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with amyotrophic lateral sclerosis or frontotemporal dementia.
Not a fit: Patients with conditions unrelated to protein aggregation or those without neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from ALS and frontotemporal dementia.
How similar studies have performed: Previous research has shown promising results in understanding protein aggregation in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Ross, Eric D — Colorado State University
- Study coordinator: Ross, Eric D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.