Understanding how certain proteins cause mutations in cancer cells
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
This study is looking at how certain proteins in cancer cells can cause changes in their DNA that make them harder to treat, and it aims to find new ways to help patients get better by understanding these changes better.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10864820 on NIH RePORTER |
What this research studies
This research investigates the role of APOBEC proteins in causing mutations within cancer cells, which can lead to treatment resistance and tumor diversity. By analyzing tumor samples and utilizing advanced sequencing technologies, the study aims to uncover the mechanisms behind genomic instability and the accumulation of mutations. The goal is to develop new strategies to combat tumor evolution and improve treatment outcomes for patients with cancer. Patients may benefit from insights that could lead to more effective therapies tailored to their specific tumor characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with various types of cancer who exhibit tumor heterogeneity and resistance to standard therapies.
Not a fit: Patients with early-stage cancers that are not yet exhibiting significant genomic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that better target the unique mutations present in individual tumors, improving patient outcomes.
How similar studies have performed: Previous research has shown that understanding mutational signatures in cancer can lead to significant advancements in treatment strategies, indicating a promising avenue for this study.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Buisson, Remi — University of California-Irvine
- Study coordinator: Buisson, Remi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.