Understanding how certain proteins cause changes in cancer cells
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
This research looks into how specific proteins called APOBEC create differences within cancer cells, which can make treatments less effective.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11127394 on NIH RePORTER |
What this research studies
Cancer cells within the same tumor can be very different, making it hard to treat and leading to resistance to chemotherapy and the spread of cancer. This project aims to understand how these differences, or "heterogeneity," develop in tumors. Researchers are focusing on a specific group of proteins called APOBEC, which are known to cause mutations in DNA. By learning more about how these proteins lead to changes in cancer cells, we hope to find new ways to stop tumors from evolving and becoming resistant to treatment.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit patients with various types of cancer by improving future treatments.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new strategies that make cancer treatments more effective by preventing tumors from becoming resistant to drugs.
How similar studies have performed: While the role of APOBEC in cancer is recognized, this specific project explores a newly observed discrepancy in how these proteins cause mutations, making its approach somewhat novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Buisson, Remi — University of California-Irvine
- Study coordinator: Buisson, Remi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.