Understanding how certain proteins cause cell death and inflammation
Official title: Revealing the Mechanisms of Cleaved and Intact GSDMD Pore Formation and Membrane Rupture
Funded at Harvard Medical School · NIH-11161933 · Data updated 2026-11-12
This study is looking at how a protein called gasdermin D helps cells die and release signals that cause inflammation, which could help us understand and improve treatments for diseases like Alzheimer's and other inflammatory conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2025 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $43,456 |
| NIH project number | 1F31AI191410-01 |
| Project ID | NIH-11161933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inflammatory diseases or neurodegenerative conditions such as Alzheimer's disease.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by neurodegenerative diseases may not benefit from this research.
What this research studies
This research investigates the mechanisms by which a specific protein, gasdermin D (GSDMD), forms pores in cell membranes, leading to cell death and the release of inflammatory signals. The study focuses on how the innate immune system detects harmful stimuli and activates a complex of proteins that can trigger inflammation. By examining the interactions between these proteins, researchers aim to uncover how dysregulation can lead to various diseases, including Alzheimer's and other inflammatory conditions. Patients may benefit from insights gained into how to better manage or treat these diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating inflammatory diseases and conditions like Alzheimer's.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammasomes in various diseases, indicating that this approach has potential for significant findings.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Healy, Liam Brendan — Harvard Medical School
- Study coordinator: Healy, Liam Brendan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.