Understanding how certain proteins bind to methylated DNA in brain cells
Identification and characterization of mCpH binding proteins in neurons
This study is looking at how a special type of DNA change in brain cells affects the way genes work, which could help us understand and improve treatments for conditions like Amyotrophic Lateral Sclerosis and other brain diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10897739 on NIH RePORTER |
What this research studies
This research investigates the role of mCpH methylation in neurons, focusing on how specific proteins interact with this form of DNA modification. By utilizing advanced techniques like ATAC sequencing, the study aims to uncover the mechanisms of transcriptional regulation in the brain, particularly in relation to conditions such as Amyotrophic Lateral Sclerosis. Patients may benefit from insights gained about the biological processes that underlie neurodevelopmental disorders and brain diseases. The research involves analyzing DNA methylation profiles to identify binding proteins that could play a role in neuronal function and health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with neurodevelopmental disorders or Amyotrophic Lateral Sclerosis.
Not a fit: Patients with conditions unrelated to neurodevelopmental disorders or those over 21 years old may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodevelopmental disorders and brain diseases.
How similar studies have performed: Other research has shown promising results in understanding DNA methylation's role in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Zhu, Heng — Johns Hopkins University
- Study coordinator: Zhu, Heng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.