Understanding how certain proteins are secreted from cells without following traditional pathways
Examining Molecular Regulation of Unconventional Cytoplasmic Protein Secretion
This study is exploring how certain proteins are released from cells in unique ways, which is important for our immune system and fighting inflammation, and it aims to find new proteins that could help us understand health and disease better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project ID | NIH-10887654 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind unconventional protein secretion, which is crucial for various biological functions. Using advanced techniques like CRISPR screening, the study aims to identify new regulators involved in this process, particularly focusing on proteins that play roles in inflammation and immunity. By employing mass-spectrometry methods, the research seeks to discover proteins that are secreted in ways that differ from the classical pathways. This could lead to a better understanding of how these proteins contribute to health and disease.
Who could benefit from this research
Good fit: Patients with conditions involving inflammatory responses or immune system dysfunction may benefit from this research.
Not a fit: Patients with unrelated health issues or those not affected by inflammatory or immune conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to inflammation and immune responses.
How similar studies have performed: Previous research has shown promise in understanding unconventional protein secretion, but this specific approach using CRISPR is relatively novel.
Where this research is happening
Maywood, United States
- Loyola University Chicago — Maywood, United States (Active)
Researchers
- Principal investigator: Abbineni, Prabhodh Sai — Loyola University Chicago
- Study coordinator: Abbineni, Prabhodh Sai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.