Understanding how certain proteins are removed from cells to prevent disease
The Discovery of Molecules and Mechanisms of the Rhomboid Superfamily
This study is looking at how a special protein called Dfm1 helps get rid of misfolded proteins in our cells, which could help us understand diseases like Alzheimer's better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11011717 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which misfolded proteins are eliminated from cells, focusing on a specific protein called Dfm1 that plays a crucial role in this process. By studying how Dfm1 helps remove these problematic proteins and regulates lipid metabolism, the research aims to uncover new insights into cellular stress responses. The approach includes advanced techniques such as whole-genome yeast arrays to explore the biological functions of Dfm1 and its impact on protein folding and degradation. This work could lead to a better understanding of diseases linked to protein misfolding, such as Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with neurodegenerative diseases associated with protein misfolding, particularly Alzheimer's disease.
Not a fit: Patients with conditions unrelated to protein misfolding or those not affected by neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by protein misfolding, potentially improving outcomes for patients with conditions like Alzheimer's.
How similar studies have performed: Previous research has shown promising results in understanding protein degradation mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Neal, Sonya Elina — University of California, San Diego
- Study coordinator: Neal, Sonya Elina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.