Understanding how certain proteins are regulated in their membrane positioning
Topological regulation of transmembrane proteins through Regulated Alternative Translocation
This study is looking at how certain proteins in our cells can change direction in their membranes, which might help us understand how cells communicate better, especially by exploring a new process involving a substance called ceramide.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11079469 on NIH RePORTER |
What this research studies
This research investigates how transmembrane proteins, which are essential for cell function, can change their orientation in the cell membrane under specific conditions. The team will explore a newly identified process called Regulated Alternative Translocation (RAT), which allows the direction of protein insertion into the endoplasmic reticulum to be reversed. By studying the role of ceramide and its interaction with proteins, the researchers aim to uncover the mechanisms behind this regulatory process. This could lead to a better understanding of cell signaling and communication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cell signaling or those interested in the biological mechanisms of transmembrane proteins.
Not a fit: Patients with conditions unrelated to cell signaling or transmembrane protein function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how proteins function in cells, potentially impacting treatments for diseases related to cell signaling.
How similar studies have performed: While the concept of protein translocation has been studied, the specific regulatory mechanism of Regulated Alternative Translocation is novel and has not been extensively tested.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Ye, Jin — Ut Southwestern Medical Center
- Study coordinator: Ye, Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.