Understanding how certain proteins are regulated in the cell nucleus
Official title: The regulation of phosphoprotein phosphatases in the nucleus
Funded at University of Connecticut Sch of Med/dnt · NIH-11078819 · Data updated 2026-11-12
This study is looking at how certain proteins, called phosphoprotein phosphatases, help control important processes in our cells, like how they grow and divide, which can affect cancer development, and it's designed for anyone interested in understanding how these proteins work and their impact on health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $362,972 |
| NIH project number | 5R01GM144379-03 |
| Project ID | NIH-11078819 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or conditions related to cell division dysregulation.
✕Less likely to help
Patients with conditions unrelated to cell signaling or those not experiencing issues with cell division may not benefit from this research.
What this research studies
This research investigates the mechanisms that control phosphoprotein phosphatases (PPP), which are crucial for regulating cellular processes like cell division and cancer progression. By focusing on specific enzymes, PP1 and PP2A, the research aims to uncover how these proteins interact with their substrates and how this regulation can impact health and disease. The study employs advanced techniques to analyze the structural and functional roles of these enzymes, providing insights into their activity during critical cellular events.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and other diseases linked to cell division errors.
How similar studies have gone: Previous research has shown promising results in understanding similar regulatory mechanisms in other cellular processes, indicating potential for success in this area as well.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Page, Rebecca — University of Connecticut Sch of Med/dnt
- Study coordinator: Page, Rebecca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.