Understanding how certain proteins are regulated in cancer cells
Official title: Structural and biochemical characterization of VCPIP1 and VCP complex
Funded at Harvard Medical School · NIH-10839306 · Data updated 2026-11-12
This study is looking at certain proteins that help control how cells break down other proteins, with the goal of finding new ways to treat cancer by targeting a specific protein called VCPIP1, which could lead to better treatment options for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $43,203 |
| NIH project number | 5F31CA281197-02 |
| Project ID | NIH-10839306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancers that may be influenced by the ubiquitin proteasome system.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers are not affected by the ubiquitin proteasome system may not benefit from this research.
What this research studies
This research investigates the role of specific proteins involved in the ubiquitin proteasome system, which is crucial for controlling protein degradation in cells. By examining the structure and function of deubiquitinating enzymes (DUBs), the study aims to develop targeted therapies that can inhibit these enzymes, potentially leading to new cancer treatments. The research focuses on a particular DUB, VCPIP1, which has been identified as a therapeutic target in various cancers. Patients may benefit from insights gained into how these proteins can be manipulated to improve cancer treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to the development of new precision therapies for cancer patients.
How similar studies have gone: Previous research has shown success in targeting components of the ubiquitin proteasome system for cancer therapy, indicating a promising avenue for further exploration.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Shah, Binita — Harvard Medical School
- Study coordinator: Shah, Binita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.