Understanding how certain proteins are made and displayed on the surface of bacteria.
Biogenesis of surface-exposed lipoproteins in Gram-negative bacteria
This study is looking at how certain proteins on the surface of bacteria like E. coli are moved to their outer layer, which is important for their survival and how they interact with our bodies, and the results could help in creating better vaccines and understanding how these bacteria avoid our immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10689085 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which surface-exposed lipoproteins (SLPs) are targeted and exported to the outer membrane of Gram-negative bacteria, such as E. coli. By utilizing genetic and biochemical techniques, the study aims to uncover the pathways that govern the localization of these proteins, which are crucial for bacterial survival and interaction with hosts. The findings could lead to the development of predictive models for identifying SLPs and understanding their roles in pathogenesis, including immune evasion and vaccine development.
Who could benefit from this research
Good fit: Patients with infections caused by Gram-negative bacteria, particularly those involving E. coli, may benefit from advancements in treatment stemming from this research.
Not a fit: Patients with infections caused by Gram-positive bacteria or non-bacterial infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for vaccine development and treatments targeting bacterial infections.
How similar studies have performed: Other research has shown success in understanding protein localization in bacteria, but the specific focus on surface-exposed lipoproteins is relatively novel.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Konovalova, Anna — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Konovalova, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.