Understanding how certain proteins are incorrectly made in neurodegenerative diseases
Defining modifiers and mechanisms of RAN translation
This study is looking into how certain proteins are made in a way that might lead to brain diseases like Alzheimer's and frontotemporal dementia, with the hope that understanding this process can help find new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11088786 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind a unique form of protein translation that may contribute to neurodegenerative diseases like Alzheimer's and frontotemporal dementia. By combining advanced techniques in biophysics and genetics, the researchers aim to uncover how these proteins are produced inappropriately and identify potential modifiers that could help mitigate neurodegeneration. Patients may benefit from insights gained into the underlying causes of their conditions, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, frontotemporal dementia, or amyotrophic lateral sclerosis (ALS).
Not a fit: Patients with neurodegenerative diseases not related to protein translation defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in understanding unconventional protein translation mechanisms in neurodegenerative diseases, suggesting potential for breakthroughs in this area.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Puglisi, Joseph D — Stanford University
- Study coordinator: Puglisi, Joseph D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.