Understanding how certain proteins are formed and function in cells
A solid state conceptualization of information transfer from gene to message to protein
This study is looking at special proteins in our cells that don't have a complex structure and how they help control important processes in the body, which could lead to new ways to understand and treat diseases related to protein problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11017713 on NIH RePORTER |
What this research studies
This research investigates the unique proteins in eukaryotic cells that contain only a limited set of amino acids, which are known to be intrinsically disordered. By exploring how these low complexity proteins contribute to cellular regulation and their role in processes like post-translational modification and alternative pre-mRNA splicing, the research aims to uncover fundamental mechanisms of protein function. The approach includes biophysical methods to study the phase separation of these proteins, which may lead to new insights into cellular processes. Patients may benefit from a better understanding of diseases linked to protein misfolding or dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to protein misfolding or disorders linked to cellular regulation.
Not a fit: Patients with conditions unrelated to protein function or cellular regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to protein misfolding and cellular regulation.
How similar studies have performed: Other research has shown success in understanding protein behavior and cellular processes, indicating that this approach has potential for significant findings.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mcknight, Steven L — Ut Southwestern Medical Center
- Study coordinator: Mcknight, Steven L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.