Understanding how certain proteins affect the movement of immune cells
Official title: Role of S1PRs and KLF transcription factors in CD8T cell trafficking
Funded at University of Minnesota · NIH-11066821 · Data updated 2026-11-12
This study is looking at how certain proteins help CD8+ T cells, which are important for fighting infections, move and behave, with the hope that understanding this could lead to better treatments for infections and immune-related issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $35,785 |
| NIH project number | 1F31AI188630-01 |
| Project ID | NIH-11066821 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with acute infections or those who may benefit from enhanced immune responses.
✕Less likely to help
Patients with chronic, non-infectious conditions or those not requiring immune modulation may not benefit from this research.
What this research studies
This research investigates the role of specific proteins in the movement and behavior of CD8+ T cells, which are crucial for the immune response against infections. By examining how these proteins influence T cell differentiation and migration, the study aims to uncover mechanisms that could enhance the effectiveness of immune responses. The approach includes genetic manipulation and analysis of gene expression to understand how these proteins interact and regulate T cell functions. Patients may benefit from insights that could lead to improved therapies for infections and immune-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in patients, particularly those with infections or immune deficiencies.
How similar studies have gone: Previous research has shown promising results in understanding T cell behavior and could support the potential success of this approach.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Depauw, Taylor a — University of Minnesota
- Study coordinator: Depauw, Taylor a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.