Understanding how certain proteins affect the development of placental cells.
Histone Demethylases and Trophoblast Differentiationt
['FUNDING_R01'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-10889986
This study is looking at how a protein called LSD1 affects the growth of important cells in the placenta that help support a healthy pregnancy, and it could help us understand issues like growth problems in babies and conditions like preeclampsia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10889986 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein, LSD1, in the development and differentiation of placental cells, which are crucial for a healthy pregnancy. By studying mouse models and human cells, the research aims to uncover how LSD1 influences the growth and function of trophoblast cells, which are essential for implantation and fetal development. The findings could provide insights into the molecular mechanisms behind pregnancy complications such as intrauterine growth restriction and preeclampsia.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals or those planning to become pregnant, particularly those at risk for pregnancy complications.
Not a fit: Patients who are not pregnant or do not plan to become pregnant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for pregnancy-related disorders.
How similar studies have performed: Previous research has shown that targeting similar molecular mechanisms can lead to significant advancements in understanding pregnancy complications, suggesting a promising avenue for this investigation.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAUL, SOUMEN — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: PAUL, SOUMEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.