Understanding how certain proteins affect the development of female reproductive cells.
Grem1 and Grem2 in embryonic ovary development
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10830913
This study is looking at how two proteins, GREMLIN-1 and GREMLIN-2, affect the development of egg cells in women, which is important for fertility, and it hopes to find new ways to help those struggling with infertility.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10830913 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins, GREMLIN-1 and GREMLIN-2, in the development of oocytes, which are crucial for female fertility. By examining how these proteins influence the number of oocytes produced during embryonic development, the research aims to uncover the molecular signals that regulate ovarian reserve and reproductive lifespan. The study will involve analyzing genetic variants associated with ovarian insufficiency and their impact on oocyte development. Patients may benefit from insights that could lead to new treatments for infertility.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing infertility or early reproductive senescence, particularly those with genetic variants linked to ovarian insufficiency.
Not a fit: Patients who are not female or those who do not have concerns related to fertility or ovarian health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility in women.
How similar studies have performed: Previous research has shown that understanding molecular signals in reproductive biology can lead to significant advancements in fertility treatments, indicating a promising avenue for this study.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PANGAS, STEPHANIE A. — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: PANGAS, STEPHANIE A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.