Understanding how certain proteins affect the development of female reproductive cells.
Official title: Grem1 and Grem2 in embryonic ovary development
Funded at Baylor College of Medicine · NIH-10830913 · Data updated 2026-11-12
This study is looking at how two proteins, GREMLIN-1 and GREMLIN-2, affect the development of egg cells in women, which is important for fertility, and it hopes to find new ways to help those struggling with infertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $316,800 |
| NIH project number | 5R01HD108153-02 |
| Project ID | NIH-10830913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility or early reproductive senescence, particularly those with genetic variants linked to ovarian insufficiency.
✕Less likely to help
Patients who are not female or those who do not have concerns related to fertility or ovarian health may not benefit from this research.
What this research studies
This research investigates the role of specific proteins, GREMLIN-1 and GREMLIN-2, in the development of oocytes, which are crucial for female fertility. By examining how these proteins influence the number of oocytes produced during embryonic development, the research aims to uncover the molecular signals that regulate ovarian reserve and reproductive lifespan. The study will involve analyzing genetic variants associated with ovarian insufficiency and their impact on oocyte development. Patients may benefit from insights that could lead to new treatments for infertility.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility in women.
How similar studies have gone: Previous research has shown that understanding molecular signals in reproductive biology can lead to significant advancements in fertility treatments, indicating a promising avenue for this study.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Pangas, Stephanie a. — Baylor College of Medicine
- Study coordinator: Pangas, Stephanie a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.