Understanding how certain proteins affect the blood-brain barrier during stroke
Endothelial Beta 1-integrins in Cerebral Vascular Barrier Integrity
This study is looking at how certain proteins in the blood-brain barrier can help protect the brain during a stroke, and it hopes to find ways to keep this barrier strong to help stroke patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10664952 on NIH RePORTER |
What this research studies
This research investigates the role of endothelial beta 1-integrins in maintaining the integrity of the blood-brain barrier, particularly during ischemic stroke. It focuses on how these proteins interact with the surrounding matrix and how their disruption can lead to increased permeability and edema in the brain. By using advanced imaging techniques and in vitro models, the study aims to identify potential interventions that could prevent damage to the blood-brain barrier and improve outcomes for stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke or are at high risk for stroke.
Not a fit: Patients with hemorrhagic stroke or other non-ischemic brain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the blood-brain barrier and reduce brain swelling after a stroke.
How similar studies have performed: Previous research has shown promise in targeting blood-brain barrier integrity, suggesting that this approach could yield significant advancements.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Del Zoppo, Gregory J — University of Washington
- Study coordinator: Del Zoppo, Gregory J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.