Understanding how certain proteins affect norovirus infection and spread
Official title: The Role of Trim Proteins in Regulating Norovirus Replication and Tropism
Funded at Ut Southwestern Medical Center · NIH-11083739 · Data updated 2026-11-12
This study is looking at how certain proteins in our bodies can help stop noroviruses from infecting cells, which could lead to new ways to treat illnesses caused by this virus, and it's being tested in mice to learn more about how noroviruses work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | May 8, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $479,089 |
| NIH project number | 5R01DK133231-03 |
| Project ID | NIH-11083739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals at high risk for norovirus infections, such as those in close living quarters or with compromised immune systems.
✕Less likely to help
Patients who are not affected by norovirus or who do not experience gastrointestinal diseases may not receive any benefit from this research.
What this research studies
This research investigates the role of specific proteins, known as TRIM proteins, in regulating how noroviruses infect cells and replicate. By using a mouse model, the study aims to uncover the mechanisms behind norovirus tropism, which is the ability of the virus to infect different types of cells and tissues. The researchers will explore how these proteins may act as barriers to norovirus replication, potentially leading to new therapeutic strategies. This work is essential for improving our understanding of norovirus biology and developing better treatments for related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for preventing and treating norovirus infections, which are a major cause of gastrointestinal illness worldwide.
How similar studies have gone: Other research has shown success in identifying viral tropism mechanisms, but the specific role of TRIM proteins in norovirus is still being explored and represents a novel area of investigation.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Orchard, Robert C. — Ut Southwestern Medical Center
- Study coordinator: Orchard, Robert C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.