Understanding how certain proteins affect muscle growth and healing
Novel mechanisms regulating muscle growth and regeneration: elucidating the Klotho/Jmjd3/Wnt axis
This study is looking at how a protein called Klotho helps muscles grow and heal by affecting special cells that repair muscle, and it's for anyone interested in improving muscle health, especially after injury or illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10843757 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called Klotho in regulating muscle growth and repair through its effects on myogenic stem cells known as satellite cells. By examining how Klotho influences the expression of another enzyme, Jmjd3, and its impact on gene activation related to muscle development, the research aims to uncover new mechanisms that could enhance muscle health. The study utilizes various biological assays to analyze cellular processes and gene expression in muscle tissues, particularly in response to injury or disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing muscle degeneration or injury, particularly those with conditions affecting muscle health.
Not a fit: Patients with stable muscle function and no history of muscle-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve muscle regeneration and function in patients with muscle-related disorders.
How similar studies have performed: Previous research has shown promising results in understanding muscle regeneration mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Tidball, James G — University of California Los Angeles
- Study coordinator: Tidball, James G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.