Understanding how certain proteins affect mast cell function in allergic diseases
Critical role for Solute Carrier Proteins (SLCs) for mast cell function
['FUNDING_R01'] · SEATTLE CHILDREN'S HOSPITAL · NIH-11089538
This study is looking at how certain proteins in mast cells, which are important for allergies, affect their behavior, with the goal of finding new ways to help manage allergic reactions better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11089538 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Solute Carrier Proteins (SLCs) in mast cells, which are crucial for allergic reactions. The study aims to identify how these proteins influence mast cell behavior, particularly in conditions like allergic inflammation. By analyzing the surface proteins of mast cells, researchers hope to uncover new therapeutic targets that can help manage allergic diseases more effectively. The approach includes examining the expression of specific proteins and their impact on mast cell activation and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from allergic diseases, particularly those with severe allergic reactions or mast cell-related conditions.
Not a fit: Patients without allergic diseases or those not affected by mast cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target mast cells, potentially reducing the severity of allergic reactions.
How similar studies have performed: Previous research has shown promising results in targeting mast cells for allergy treatment, indicating that this approach could be a significant advancement in the field.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PILIPONSKY, ADRIAN M — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: PILIPONSKY, ADRIAN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease