Understanding how certain proteins affect male fertility in mice
Official title: Identifying the Molecular Function of the Y-linked Mouse Zinc Finger Proteins ZFY1 and ZFY2
Funded at University of Hawaii at Manoa · NIH-10909857 · Data updated 2026-11-12
This study is looking at how two proteins, ZFY1 and ZFY2, affect sperm development in male mice, which could help us learn more about male fertility and lead to new treatments for fertility issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | August 4, 2023 |
| Project end | August 3, 2026 |
| Funding year | 2024 |
| Award (this year) | $34,974 |
| NIH project number | 5F31HD111279-02 |
| Project ID | NIH-10909857 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men experiencing infertility issues, particularly those with suspected genetic factors affecting sperm production.
✕Less likely to help
Patients with infertility not related to genetic factors or those who are not male may not benefit from this research.
What this research studies
This research investigates the role of two specific proteins, ZFY1 and ZFY2, in male fertility by studying their effects on sperm development in mice. The researchers will use advanced techniques like CRISPR to manipulate these proteins and analyze their impact on spermatogenesis, which is the process of sperm cell development. By examining germ cells from genetically modified mice, they aim to identify the genes regulated by these proteins and understand their biochemical functions through various assays. This work could provide insights into male reproductive health and potential fertility treatments.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating male infertility.
How similar studies have gone: Previous studies have shown that understanding the molecular mechanisms of fertility can lead to significant advancements in reproductive health, suggesting this approach has potential for success.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Holmlund, Hayden Robert — University of Hawaii at Manoa
- Study coordinator: Holmlund, Hayden Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.