Understanding how certain proteins affect male fertility and sperm production
Investigating the role of bromodomain-containing proteins in the production of viable spermatozoa and male fertility
This study is looking at how certain proteins help with sperm production, which is important for male fertility, by exploring how changes in these proteins can affect sperm shape and quality.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11083779 on NIH RePORTER |
What this research studies
This research investigates the role of bromodomain-containing proteins in the process of sperm production, which is crucial for male fertility. It focuses on how these proteins regulate gene expression during key stages of sperm development, particularly meiotic prophase I and spermiogenesis. By studying mutations in specific genes related to these proteins, the research aims to uncover the mechanisms behind sperm morphology defects and poor semen quality, which contribute to male infertility. The approach includes analyzing the interactions of these proteins and their effects on chromatin structure and transcriptional control.
Who could benefit from this research
Good fit: Ideal candidates for this research are men experiencing infertility due to sperm morphology defects or poor semen quality.
Not a fit: Patients who do not have issues related to sperm production or morphology, or those with infertility due to non-genetic factors, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for male infertility, improving the chances of conception for affected individuals.
How similar studies have performed: Previous research has shown promising results in understanding the role of gene regulation in spermatogenesis, indicating that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Cohen, Paula Elaine — Cornell University
- Study coordinator: Cohen, Paula Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.