Understanding how certain proteins affect lung cancer growth
Identifying and Targeting Mechanisms for Membrane Signaling in Human Cancer
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10986093
This study is looking at how certain proteins affect the growth and survival of lung cancer cells, specifically adenocarcinoma, to find new ways to help patients feel better and live longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10986093 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of membrane signaling in lung cancer, specifically focusing on adenocarcinoma, the most common subtype of non-small cell lung cancer. The study aims to explore the roles of specific proteins, RhoA and RAP1GDS1, in cancer cell proliferation and survival. By utilizing advanced techniques in cell biology and proteomics, researchers will analyze how the loss of these proteins impacts cancer growth in three-dimensional models. The findings could lead to new therapeutic strategies targeting these pathways to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those with the adenocarcinoma subtype.
Not a fit: Patients with other types of lung cancer or those without a diagnosis of lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms driving lung cancer, potentially improving survival rates for patients.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating that this approach may be effective.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWEET-CORDERO, ERIC ALEJANDRO — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SWEET-CORDERO, ERIC ALEJANDRO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.