Understanding how certain proteins affect liver injury from acetaminophen
HSPG Interactions in Liver Disease
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11084401
This study is looking at how certain proteins in the liver might help it heal after damage from too much acetaminophen, with the hope of finding new ways to help people recover from liver injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11084401 on ClinicalTrials.gov |
What this research studies
This research investigates the role of heparan sulfate proteoglycans (HSPGs) in the liver's response to acetaminophen-induced liver injury. It focuses on how these proteins interact with various factors that contribute to liver damage and recovery. By studying mice with specific genetic modifications, the researchers aim to uncover mechanisms that could enhance liver repair after injury. The ultimate goal is to identify potential therapeutic strategies that could improve outcomes for patients suffering from liver damage due to acetaminophen overdose.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acetaminophen overdose or are at risk for acetaminophen-induced liver injury.
Not a fit: Patients who have liver injuries caused by factors other than acetaminophen may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance liver recovery and reduce the severity of liver injury from acetaminophen overdose.
How similar studies have performed: Previous research has shown promising results in understanding liver injury mechanisms, but this specific approach focusing on HSPGs is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK, PYONG WOO — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: PARK, PYONG WOO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acetaminophen-induced liver injury, Acute Disease, acute disease/disorder, acute disorder