Understanding how certain proteins affect liver disease progression to cancer
Official title: Project 1: Control of NASH to HCC progression by the NRF2-FBP1 tug-of-war
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-10935865 · Data updated 2026-11-12
This study is looking at how two proteins in the liver might help us understand how non-alcoholic fatty liver disease can lead to liver cancer, with the hope of finding new treatments that could help patients like you.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $573,624 |
| NIH project number | 1P01CA281819-01A1 |
| Project ID | NIH-10935865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis (NASH) who are at risk of developing liver cancer.
✕Less likely to help
Patients with liver cancer who do not have a history of NASH may not benefit from this research.
What this research studies
This research investigates the roles of two important proteins, NRF2 and FBP1, in the progression of non-alcoholic steatohepatitis (NASH) to hepatocellular carcinoma (HCC). By examining how these proteins interact and influence liver cell metabolism, the study aims to uncover mechanisms that could lead to new treatment strategies. The research involves both laboratory experiments and analysis of human liver samples to understand the cellular changes that occur during disease progression. Patients may benefit from insights gained that could lead to targeted therapies for liver disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of liver disease to cancer.
How similar studies have gone: Previous research has shown promising results in understanding the molecular mechanisms of liver disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Karin, Michael — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Karin, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.