Understanding how certain proteins affect kidney blood vessel injury
Official title: Transcriptional Regulation of Thrombotic Microangiopathy in the Renal Microvasculature
Funded at Northport VA Medical Center · NIH-10948891 · Data updated 2026-11-12
This study is looking at a serious kidney problem called thrombotic microangiopathy (TMA) to learn how certain proteins and inflammation affect it, with the hope of finding ways to protect your kidneys and help you feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northport VA Medical Center NIH-funded |
| Lab location | 1 site (Northport, United States) |
| Project start | October 1, 2021 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK2BX005380-04 |
| Project ID | NIH-10948891 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with thrombotic microangiopathy or those experiencing related kidney issues.
✕Less likely to help
Patients with kidney conditions unrelated to thrombotic microangiopathy may not benefit from this research.
What this research studies
This research investigates the severe kidney condition known as thrombotic microangiopathy (TMA), which leads to significant damage in kidney blood vessels. The study focuses on understanding how specific proteins and inflammatory responses contribute to this condition, using advanced techniques like RNA sequencing from kidney biopsy samples. By examining the role of a particular transcription factor, KLF4, the research aims to uncover mechanisms that could help prevent kidney damage and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate kidney damage in patients with thrombotic microangiopathy.
How similar studies have gone: While the specific focus on KLF4 in renal microvascular injury is novel, previous studies have shown success in understanding similar mechanisms in other vascular conditions.
Where this research is happening
-
Northport VA Medical Center
Northport, United States Active
Researchers
- Principal investigator: Estrada, Chelsea — Northport VA Medical Center
- Study coordinator: Estrada, Chelsea
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.