Understanding how certain proteins affect inflammation in whooping cough
Pertussis inflammation is mediated by a balance between peptidoglycan recognition proteins-1 and -4
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11014440
This study is looking at how certain proteins affect inflammation caused by whooping cough, with the hope of finding new treatments that work better than just antibiotics for people suffering from this serious respiratory illness.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11014440 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins in the inflammatory response associated with whooping cough, a serious respiratory illness. The team aims to develop new treatments by focusing on how these proteins interact with bacterial components and influence inflammation. By studying the effects of S1PR agonists in animal models, the researchers hope to identify new therapeutic strategies that could improve patient outcomes. The ultimate goal is to create effective anti-pertussis therapies that go beyond traditional antibiotics.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for whooping cough or those experiencing symptoms of the disease.
Not a fit: Patients who have already received effective treatment for whooping cough or those without the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for whooping cough that are more effective than current antibiotic therapies.
How similar studies have performed: Other research has shown promise in targeting inflammatory responses in bacterial infections, suggesting that this approach could be beneficial.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SKERRY, CIARAN — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: SKERRY, CIARAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.