Understanding how certain proteins affect inflammation in the gut
Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal Inflammation
This study is looking at how certain proteins affect inflammation and immune cells, which could help us find new ways to treat conditions like arthritis and heart disease, so patients can better manage their symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10628032 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins in regulating inflammation, particularly focusing on how they influence immune cells called macrophages. By examining the mechanisms that lead to chronic inflammatory disorders like arthritis and atherosclerosis, the study aims to uncover new therapeutic targets. Patients may benefit from insights into how to better manage or treat their inflammatory conditions through novel immunologic therapies. The research employs advanced bioinformatics and molecular biology techniques to explore these interactions.
Who could benefit from this research
Good fit: Ideal candidates include individuals suffering from chronic inflammatory conditions such as arthritis, atherosclerosis, or inflammatory bowel disease.
Not a fit: Patients with acute inflammatory conditions or those not affected by chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage chronic inflammatory diseases.
How similar studies have performed: Other research has shown promise in targeting macrophage polarization for treating chronic inflammation, indicating a potential for success in this approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ghosh, Pradipta — University of California, San Diego
- Study coordinator: Ghosh, Pradipta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.