Understanding how certain proteins affect inflammation during influenza virus infections
The Role of TRIM6 and Ubiquitin in Influenza Virus-Induced Pathology
This study is looking at how certain proteins in the body help control inflammation when someone gets the flu, using special mice without one of these proteins to see how it affects their immune response, with the hope of finding better ways to help people with the flu feel better while reducing harmful inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10828730 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins, TRIM6 and ubiquitin, in managing inflammation caused by the influenza A virus. By studying genetically modified mice that lack TRIM6, researchers aim to uncover how these proteins influence the immune response and inflammation levels during infection. The goal is to find ways to enhance the body's tolerance to the virus while minimizing harmful inflammation, which could lead to better treatment strategies for patients suffering from influenza.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of severe influenza infections, particularly those with underlying health conditions that may exacerbate their response to the virus.
Not a fit: Patients who are not affected by influenza or those who have already been vaccinated against the virus may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce severe inflammation in patients with influenza, improving their recovery and overall health outcomes.
How similar studies have performed: Previous research has shown that manipulating inflammatory responses can lead to improved outcomes in viral infections, suggesting that this approach may yield promising results.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Rajsbaum, Ricardo — Rutgers Biomedical and Health Sciences
- Study coordinator: Rajsbaum, Ricardo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.