Understanding how certain proteins affect immune cells in multiple sclerosis
TGF-b superfamily signaling in controlling Th17 cell function in autoimmune neuroinflammation
This study is looking at how certain proteins affect a type of immune cell that plays a big role in multiple sclerosis, with the hope of finding new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11003264 on NIH RePORTER |
What this research studies
This research investigates the role of the TGF-β superfamily in regulating Th17 cells, which are crucial in the development of multiple sclerosis (MS). By examining how these proteins influence T cell function, the study aims to uncover new mechanisms that contribute to autoimmune neuroinflammation. The approach includes both in vitro and in vivo experiments to analyze the effects of specific proteins on Th17 cell differentiation and function. Patients may benefit from insights that could lead to novel therapeutic strategies for MS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis or those experiencing symptoms of autoimmune neuroinflammation.
Not a fit: Patients with other types of autoimmune diseases that do not involve Th17 cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even prevent multiple sclerosis.
How similar studies have performed: Previous research has shown promising results in understanding TGF-β signaling in autoimmune conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Wan, Yisong — Univ of North Carolina Chapel Hill
- Study coordinator: Wan, Yisong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.