Understanding how certain proteins affect hormone sensitivity in uterine fibroids
Official title: REST-MED12 Pathways in the Regulation of Estrogen - Progesterone Sensitivity in Uterine Leiomyoma
Funded at University of Kansas Medical Center · NIH-11171730 · Data updated 2026-11-12
This study is looking into how certain proteins in the body affect the growth of uterine fibroids, which are non-cancerous tumors that can impact women's health, to help find new ways to treat this common issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 16, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $529,820 |
| NIH project number | 5R01HD113717-02 |
| Project ID | NIH-11171730 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of childbearing age who are experiencing symptoms related to uterine fibroids.
✕Less likely to help
Patients who do not have uterine fibroids or are not of childbearing age may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind uterine fibroids, which are benign tumors that can affect women's reproductive health. The study focuses on two key proteins, REST and MED12, which are involved in the regulation of hormone sensitivity in these tumors. By using genetically modified mouse models, researchers aim to uncover how the loss or mutation of these proteins contributes to the development of uterine fibroids. The findings could lead to the identification of new therapeutic targets for treating this common condition.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective long-term treatments for uterine fibroids, potentially reducing the need for surgeries like hysterectomy.
How similar studies have gone: Previous research has shown promising results in understanding the molecular pathways involved in uterine fibroids, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Chennathukuzhi, Vargheese Mani — University of Kansas Medical Center
- Study coordinator: Chennathukuzhi, Vargheese Mani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.