Understanding how certain proteins affect heart function and signaling
Official title: Desensitization of beta1 adrenergic receptor-nitric oxide signaling in cardiac diseases
Funded at VA Northern California Health Care Sys · NIH-11087671 · Data updated 2026-11-12
This study is looking at how certain proteins affect heart function, especially how they interact with a key receptor and nitric oxide, to help find new ways to improve heart health for people with heart conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Northern California Health Care Sys NIH-funded |
| Lab location | 1 site (Mather, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005100-05 |
| Project ID | NIH-11087671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart diseases, particularly those experiencing heart failure or related conditions.
✕Less likely to help
Patients without any cardiac conditions or those who do not respond to adrenergic signaling may not benefit from this research.
What this research studies
This research investigates the role of specific proteins in the signaling pathways that regulate heart function, particularly focusing on the β1 adrenergic receptor and its interaction with nitric oxide. The study aims to understand how these proteins, including SAP97 and GRK5, influence heart contractility and may contribute to heart diseases. By examining these mechanisms, the research seeks to identify potential targets for improving heart function in patients with cardiac conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart function and improve outcomes for patients with heart disease.
How similar studies have gone: Other research has shown promising results in understanding adrenergic signaling pathways, indicating that this approach could lead to meaningful advancements in cardiac treatment.
Where this research is happening
-
VA Northern California Health Care Sys
Mather, United States Active
Researchers
- Principal investigator: Xiang, Yang K — VA Northern California Health Care Sys
- Study coordinator: Xiang, Yang K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.