Understanding how certain proteins affect heart development and function
Mechanism and Function of Cardiac Transcriptional Repression Networks
This study is looking at how a protein called CHD4 helps control the genes that are important for heart development, which could help us understand and find new treatments for congenital heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10895480 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, CHD4, in regulating gene expression related to heart development. By examining how CHD4 interacts with other proteins to modify the structure of DNA in heart cells, the study aims to uncover mechanisms that lead to congenital heart disease. The approach includes laboratory experiments to analyze gene activity and the effects of genetic mutations on heart function. Patients may benefit from insights that could lead to new treatments for heart defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old with congenital heart defects or structural heart abnormalities.
Not a fit: Patients with heart conditions unrelated to genetic factors or those without congenital heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital heart disease.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in heart development, suggesting that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Conlon, Frank Leo — Univ of North Carolina Chapel Hill
- Study coordinator: Conlon, Frank Leo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.